The Blue Devils could not get anything out of their bench, allowing the Spartans to takeover late in the game.
Duke-Central Florida will feature college basketball's tallest player in Tacko Fall and its most exciting in Zion Williamson.
Old Dominion easily finished first in conference play and even handed a ranked opponent, then-No. 25 Syracuse, a loss on the Orange's home floor.
Mississippi State will be making its 11th appearance in the NCAA tournament—this year being its first since 2009—when it lost to Washington in the Round of 64.
This year marks the second berth into the NCAA tournament in that time span for the Norse, a remarkable feat for a program that just became eligible for Division I postseason competition in 2016.
Duke will need Tre Jones' defensive pressure to limit offensive opportunities for the Tigers.
The Blue Devils held Lipscomb without a shot for the first 67 minutes of their Round of 32 match.
Duke showed it could still be dominant if one of its star freshman does not play well against Eastern Michigan.
Behind a historic performance from Daniel Jones, Duke defeated its archival North Carolina Saturday.
